MicroRNA-149 is downregulated in Alzheimer’s disease and inhibits β-amyloid accumulation and ameliorates neuronal viability through targeting BACE1

Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) plays a critical role in Alzheimer’s disease (AD) pathogenesis. This study aimed to investigate the relationship between microRNA-149 (miR-149) and BACE1, evaluate clinical significance biological function of miR-149 AD progression. Bioinformatics analysis luciferase reporter assay were used confirm interaction BACE1. Expression BACE1 was estimated using quantitative real-time PCR. The diagnosis severity determination evaluated ROC analysis. effect on Aβ accumulation neuronal viability analyzed Aβ-treated SH-SY5Y cells. found directly binding 3’-UTR negatively correlated with patients cell model. Serum expression downregulated served as potential diagnostic biomarker. overexpression cells resulted inhibited enhanced viability. demonstrated that serum is decreased serves candidate biomarker, may suppress promote by targeting model